Endocrine Abstracts

Introduction: Irisin is a newly discovered adipo-myokine, that has a significant influence on body metabolism. Available data about this peptide is still insufficient. The aim of the study is to provide some initial information about body distribution of irisin in rats.Methods: The studied group consisted of 27 10-week-old female Wistar rats, which received intraperitoneally ~0.7 mcCi of iodine-125 labeled irisin. The studied rats were divided on five su...

Introduction: Thyroid hemiagenesis (TH) is characterised by congenital absence of one thyroid lobe.Aim: To assess possible association between TH and concomitant alterations of other structures derived from pharyngeal apparatus, which might potentially impact calcium-phosphate balance.Materials and methods: Studied group: 20 patients with TH. Control group: 20 subjects with bilobed thyroid, matched for age and gender. Serum concent...

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as developmental failure of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism. In contrast, subjects presenting TH were only sporadically involved. In addition, whether the same factors are responsible for development of TH and other forms of thyroid dysgenesis is still to be elucidated. Recent stud...

Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as failure of the development of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism; in contrast, subjects presenting TH were only sporadically involved. Changes in transcription factor genes, including TTF1, TTF2 and PAX8, which play an important role in thyroid embryogenesis, have been postu...